Epidemiology and clinical aspects of edible mushroom-related paediatric poisonings in Italy: 10-year retrospective study

Authors

  • Francesca Assisi Poison Control Centre in Milan, Niguarda Cà Granda Hospital, Italy
  • Sara Cordoni Queen Elizabeth University Hospital, 1345 Govan Rd, Glasgow, G51 4TF, United Kingdom
  • Martina Ghezzi Polytechnic University of Milan
  • Ilaria Rebutti Poison Control Centre in Milan, Niguarda Cà Granda Hospital, Italy
  • Andrea Stella Poison Control Centre in Milan, Niguarda Cà Granda Hospital, Italy
  • Alfredo Vizzini Department of Life Sciences and Systems Biology, University of Turin, Viale P.A. Mattioli, 10125 Turin, Italy

DOI:

https://doi.org/10.6092/issn.2531-7342/21730

Keywords:

poisonous edible mushrooms, treatment, outcome, Milan Poison Control Centre, children

Abstract

Intoxications caused by mushrooms (mycetisms) account for only 2% of the total toxicological consultations that the Milan Poison Control Centre receives and manages every year, but they are certainly the most challenging, both because they are potentially very dangerous and for the simultaneous involvement of multiple subjects, especially when patients are of paediatric age. The present retrospective study aims to analyse epidemiological data and the clinical course of edible mushroom poisonings in Italy. Only intoxications caused by edible mushrooms in paediatric patients were selected. Age information was missing for patients involved in collective exposures, so it is noticeable that the collected data are only a minority of real cases. The average number of vitamins, proteins and mineral salts in mushrooms is negligible, from a nutritional point of view; therefore, the results of our study show that it is preferable to avoid their consumption in children. In order to have more accurate data on the extent of mushroom-related problems in children, a nationwide homogeneous statistical survey is needed.

References

Anonymous (1997a) Position statements: gastric lavage. American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicologists. Journal of Toxicology: Clinical Toxicology 35:711-719. https://doi.org/10.3109/15563659709162568

Anonymous (1997b) Position statements: a single-dose activated Charcoal. American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicologists. Journal of Toxicology: Clinical Toxicology 35:721–741. https://doi.org/10.3109/15563659709162569

Arola H, Koivula T, Karvonen AL, Jokela H, Ahola T, Isokoski M (1999) Low trehalase activity is associated with abdominal symptoms caused by edible mushrooms. Scandinavian Journal of Gastroenterology 34(9):898‒903. https://doi.org/10.1080/003655299750025372

Assisi F, Davanzo F, Bissoli M, Dimasi V, Ferruzzi M, Georgatos J, Rebutti I, Travaglia A, Severgnini P, Sesana F, Milanesi G, Moro PA (2019) Epidemiologia e clinica delle intossicazioni da funghi in Italia: valutazione retrospettiva di 20 anni (1998-2017) del Centro Antiveleni di Milano. Istituto Superiore di Sanità, Bollettino Epidemiologico Nazionale 32(4):5‒9.

Assisi F, Settimi L, Bissoli M, Borghini R, Della Puppa T, Dimasi V, Ferruzzi M, Moro PA, Georgatos J, Rebutti I, Travaglia A, Severgnini P, Sesana F, Milanesi G, Davanzo F (2014) Surveillance of mushroom-related poisonings in Italy. Abstracts of the XXXIV International Congress of the European Association of Poisons Centres and Clinical Toxicologists (EAPCCT), 27–30 May 2014, Brussels, Belgium. Clinical Toxicology 52(4):385‒386. https://doi.org/10.3109/15563650.2014.906213

Borghi E (2019) Valori nutrizionali dei funghi più comuni in commercio. Centro Studi per la Flora Mediterranea, Borgotaro, Italy. www.ausl.pr.it

Dimopoulo M, Kolonas A, Mourtakos S, Androutsos O, Gortzi O (2022) Nutritional composition and biological properties of sixteen edible mushroom species. Applied Sciences 12(16):8074. https://doi.org/10.3390/app12168074

Fiori G, Spada C, Soru P, Tontini GE, Bravi I, Cesana BM, Cesaro P, Manes G, Orsatti A, Prada A, Quadarella A, Schettino M, Spina L, Trovato C, Carnovali M, Vecchi M (2022) Pharmacokinetics of oral mannitol for bowel preparation for colonoscopy. Clinical and Translational Science 15(10):2448‒2457. https://doi.org/10.1111/cts.13373

Gawlikowski T, Romek M, Satora L (2014) Edible mushroom-related poisoning: a study on circumstances of mushroom collection, transport, and storage Human. Experimental Toxicology 34(7):718‒724. https://doi.org/10.1177/0960327114557901

Heinzelmann R, Dutech C, Tsykun T, Labbé F, Soularue JP, Prospero S (2019) Latest advances and future perspectives in Armillaria research. Canadian Journal of Plant Pathology 41(1):1–23. https://doi.org/10.1080/07060661.2018.1558284

Holsen DS, Aarebrot S (1997) Poisonous mushrooms, mushroom poisons and mushroom poisoning. A review. Tidsskrift for den Norske Laegeforening: Tidsskrift for Praktisk Medicin, ny Raekk 117(23):3385-3388.

Kalač P (2013) A review of chemical composition and nutritional value of wild-growing and cultivated mushrooms. Journal of the Science of Food and Agriculture 93(2):209‒218. https://doi.org/10.1002/jsfa.5960

Koletzko B (2008) Basic concepts in nutrition: nutritional needs of children and adolescents. e-SPEN, the European e-Journal of Clinical Nutrition and Metabolism 3(4):e179‒e184. https://doi.org/10.1016/j.eclnm.2008.04.007

Leonardi M, Paolocci F, Rubini A, Simonini G, Pacioni G (2005) Assessment of inter- and intra-specific variability in the main species of Boletus edulis complex by ITS analysis. FEMS Microbiology Letters 243(2):411–416. https://doi.org/10.1016/j.femsle.2005.01.003

Mleczek M, Siwulski M, Budka A, Mleczek P, Budzyńska S, Szostek M, Kuczyńska-Kippen N, Kalač P, Niedzielski P, Gąsecka M, Goliński P, Magdziak Z, Rzymski P (2021) Toxicological risks and nutritional value of wild edible mushroom species -a half-century monitoring study. Chemosphere 263:128095. https://doi.org/10.1016/j.chemosphere.2020.128095

Montalto M, Gallo A, Ojetti V, Gasbarrini A (2013) Fructose, trehalose and sorbitol malabsorption. European Review for Medical and Pharmacological Sciences 17(Suppl 2):26‒29. https://www.europeanreview.org/wp/wp-content/uploads/026-0291.pdf

Paoletti MG, Norberto L, Damini R, Musumeci S (2007) Human gastric juice contains chitinase that can degrade chitin. Annals of Nutrition and Metabolism 51(3):244‒251. https://doi.org/10.1159/000104144

Radlović N (2010) Disaccharide intolerance. Srpski arhiv za celokupno lekarstvo 138(11‒12):777‒782.

Reis FS, Barros L, Martins A, Ferreira ICFR (2012) Chemical composition and nutritional value of the most widely appreciated cultivated mushrooms: an inter-species comparative study. Food and Chemical Toxicology 50(2):191‒197. https://doi.org/10.1016/j.fct.2011.10.056

Ruiz-Capillas C, Herrero AM (2019) Impact of biogenic amines on food quality and safety. Foods 8(2):62. https://doi.org/10.3390/foods8020062

Senila M, Senila L, Resz MA (2024) Chemical composition and nutritional characteristics of popular wild edible mushroom species collected from North-Western Romania. Journal of Food Composition and Analysis 134:106504. https://doi.org/10.1016/j.jfca.2024.106504

Sesana F, Assisi F, Borghini R, Celentano A, Ferruzzi M, Molino L, Davanzo F (2015) Pediatric mushrooms poisoning: a fairy tale to warn children and adults. Abstracts of the XXXV International Congress of the European Association of Poisons Centres and Clinical Toxicologists (EAPCCT), 26–29 May 2015, St Julian’s, Malta. Clinical Toxicology 53:344. https://doi.org/10.3109/15563650.2015.1024953

Sitta N, Angelini C, Balma M, Berna C, Bertocchi C, Bragalli A, Cipollone R, Corrias S, Donini M, Ginanneschi L, Gioffi D, Golzio F, Granati P, Panata M, Tani O, Tursi A, Suriano E (2020) I funghi che causano intossicazioni in Italia. Analisi dei dati provenienti da centri micologici di differenti regioni e valutazioni complessive sulle intossicazioni da specie commestibili. Proceedings of the VI International Conference of Mycotoxicology, Perugia 23-24 November 2018, Associazione Micologica bresaola, Centro Studi Micologici, Trento, Italy. Pagine di Micologia, I part 41:23‒80. https://www.researchgate.net/publication/343153164

Solomon PS, Waters ODC, Oliver RP (2007) Decoding the mannitol enigma in filamentous fungi. Trends in Microbiology 15(6):257–262. https://doi.org/10.1016/j.tim.2007.04.002

Vetter J (2003) Chemical composition of fresh and conserved Agaricus bisporus mushroom. European Food Research and Technology 217:10–12. https://doi.org/10.1007/s00217-003-0707-2

Zhong W, Shahbaz O, Teskey G, Beever A, Kachour N, Venketaraman V, Darmani NA (2021) Mechanisms of nausea and vomiting: current knowledge and recent advances in intracellular emetic signaling systems. International Journal of Molecular Sciences 22(11):5797. https://doi.org/10.3390/ijms22115797

Published

2025-12-15

How to Cite

Assisi, F., Cordoni, S., Ghezzi, M., Rebutti, I., Stella, A., & Vizzini, A. (2025). Epidemiology and clinical aspects of edible mushroom-related paediatric poisonings in Italy: 10-year retrospective study. Italian Journal of Mycology, 54(1), 235–243. https://doi.org/10.6092/issn.2531-7342/21730

Issue

Section

Articles